Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation
نویسندگان
چکیده
منابع مشابه
Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis.
RATIONALE Gastroesophageal reflux (GER) is highly prevalent in patients with idiopathic pulmonary fibrosis (IPF). Chronic microaspiration secondary to GER may play a role in the pathogenesis and natural history of IPF. OBJECTIVES To investigate the relationship between GER-related variables and survival time in patients with IPF. METHODS Regression analysis was used to investigate the relat...
متن کاملGastroesophageal reflux and idiopathic pulmonary fibrosis: A long term relationship
Idiopathic pulmonary fibrosis (IPF) is a dreaded disease of uncertain etiology and no available cure. It is still unclear if a causal relationship exists between gastro-esophageal reflux (GER) and IPF, but studies have shown an increased prevalence of acid reflux in patients with IPF. We describe a patient with achalasia and GER who went on to develop IPF. She underwent a rapidly worsening cour...
متن کاملGastroesophageal Reflux and Idiopathic Pulmonary Fibrosis: A Review
The histological counterpart of idiopathic pulmonary fibrosis is usual interstitial pneumonia, in which areas of fibrosis of various ages are interspersed with normal lung. This pattern could be explained by repeated episodes of lung injury followed by abnormal wound healing responses. The cause of the initiating alveolar epithelial injury is unknown, but postulated mechanisms include immunolog...
متن کاملPrevalence of gastroesophageal reflux disease in patients with idiopathic pulmonary fibrosis.
OBJECTIVE To determine the prevalence of gastroesophageal reflux disease (GERD) and to evaluate its clinical presentation, as well as the esophageal function profile in patients with idiopathic pulmonary fibrosis (IPF). METHODS In this prospective study, 28 consecutive patients with IPF underwent stationary esophageal manometry, 24-h esophageal pH-metry and pulmonary function tests. All patie...
متن کاملReflux in idiopathic pulmonary fibrosis.
Gastro-oesophageal reflux disease (GORD) was first implicated in the pathogenesis of pulmonary fibrosis in 1976. Idiopathic Pulmonary Fibrosis presents most commonly in the six decade of life and has a dismal median survival of 2–3 years. There have been significant and encouraging increases in knowledge underpinning key mechanisms of pathogenesis in terms of angiogenesis, signaling pathways, p...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2007
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2006.09.085